The Metabolic Imaging Journal Club is an opportunity for graduate students, post-docs and faculty to discuss current research in metabolic imaging and spectroscopy. The goals of this journal club are to promote discussion of current research in the field as well as to foster collaborations among scientists both within the VUIIS and throughout the university.

For the spring semester we will discuss two general topics: fMRI of skletal muscle and brain. Three sessions will be devoted to each topic. The format of the journal club has changed somewhat from last semester:

• Option 1: Volunteers may present either their own current data or a research proposal
• Option 2: Volunteers may present a metabolic imaging relevant paper published in the last 6 months from a peer reviewed journal

The Metabolic Imaging Journal Club will meet every other Tuesday starting on February 3rd in the VUIIS classroom, MCN AA-1119, located on the first floor of the VUIIS. The VUIIS main entrance is on Medical Center Drive facing the Medical Center East parking garage. Enter the VUIIS building through the double doors at the bottom of the stairs and go up to the first floor. Just past the elevator there is a hallway – room AA119 is located at the end of this hallway on the left.

Please see the schedule below for a list of topics, presenters and links to papers for discussion as well as relevant review articles. If you have further questions, please contact Ted Towse (theodore.f.towse@vanderbilt.edu).

• Anderson AW, Heptulla RA, Driesen N, Flanagan D, Goldberg PA, Jones TW, Rife F, Sarofin H, Tamborlane W, Sherwin R, Gore JC. Effects of hypoglycemia on human brain activation measured with fMRI. Magn Reson Imaging 2006 Jul;24(6):693-7.
• Driesen NR, Goldberg PA, Anderson AW, Tang L, Flanagan DE, Sherwin RS, Gore JC. Hypoglycemia reduces the blood-oxygenation level dependent signal in primary auditory and visual cortex: a functional magnetic resonance imaging study. J Neurosci Res. 2007 Feb 15;85(3):575-82.

• Virostko J, Jansen ED, Powers AC. Current status of imaging pancreatic islets. Curr Diab Rep. 2006 Aug;6(4):328-32.
• Gaglia JL. Noninvasive imaging of islet transplantation and rejection. Curr Diab Rep. 2007 Aug;7(4):309-13.
• Del Prato S, Bianchi C, Marchetti P. Beta-cell function and anti-diabetic pharmacotherapy. Diabetes Metab Res Rev. 2007 Oct;23(7):518-27.

• Evgenov NV, Medarova Z, Dai G, Bonner-Weir S, Moore A. In vivo imaging of islet transplantation. Nat Med. 2006 Jan;12(1):144-8.
• Gimi B, Leoni L, Oberholzer J, Braun M, Avila J, Wang Y, Desai T, Philipson LH, Magin RL, Roman BB. Functional MR microimaging of pancreatic beta-cell activation. Cell Transplant. 2006;15(2):195-203.

• Souza F, Simpson N, Raffo A, Saxena C, Maffei A, Hardy M, Kilbourn M, Goland R, Leibel R, Mann JJ, Van Heertum R, Harris PE. Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. J Clin Invest. 2006 Jun;116(6):1506-13.
• Kung MP, Hou C, Lieberman BP, Oya S, Ponde DE, Blankemeyer E, Skovronsky D, Kilbourn MR, Kung HF. In vivo imaging of beta-cell mass in rats using 18F-FP-(+)-DTBZ: a potential PET ligand for studying diabetes mellitus. J Nucl Med. 2008 Jul;49(7):1171-6.

• Speier S, Nyqvist D, Cabrera O, Yu J, Molano RD, Pileggi A, Moede T, Köhler, Wilbertz J, Leibiger B, Ricordi C, Leibiger IB, Caicedo A, Berggren P-O. Noninvasive in vivo imaging of pancreatic islet cell biology. Nature Medicine 2008;14:574-8.

• Antuna-Puente B, Feve B, Fellahi S, Bastard J-P. Adipokines: the missing link between insulin resistance and obesity. Diabetes Metab 2008;34(1):2-11.
• Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B. Recent advances in the relationship between obesity, inflammation, and insulin resistance. European Cytokine Network 2006;17(1):4-12.
• De Ferranti S, Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem 2008;54(6):945-55.

• Kriketos AD, Greenfield JR, Peake PW, Furler SM, Denyer GS, Charlesworth JA, Campbell LV. Inflammation, insulin resistance, and adiposity: a study of first-degree relatives of type 2 diabetic subjects. Diabetes Care 2004;27(8):2033-40.

• Tesauro M, Rizza S, Iantorno M, Campia U, Cardillo C, Lauro D, Leo R, Turriziani M, Cocciolillo GC, Fusco A, Panza JA, Scuteri A, Federici M, Lauro R, Quon MJ. Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus. Metabolism 2007;56(3):413-9.

• McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, Unger R, Levine BD, Raskin P, Victor RG, Szczepaniak LS. Cardiac Steatosis in Diabetes Mellitus: A 1H-Magnetic Resonance Spectroscopy Study. Circulation 2007;116(10):1170-75.
• Vinereanu D, Nicolaides E, Tweddel AC, Madler CF, Holst B, Boden LE, Cinteza M, Rees AE, Fraser AG. Subclinical left ventricular dysfunction in asymptomatic patients with type II diabetes mellitus, related to serum lipids and glycated haemoglobin. Clin Sci (Lond.) 2003;105(5):591-9.

• Matsuoka S, Hunsaker AR, Gill RR, Jacobson FL, Ohno Y, Patz S, Hatabu H. Functional MR imaging of the lung. Magn Reson Imaging Clin N Am 2008 May;16(2):275-89, ix.
• Fain SB, Korosec FR, Holmes JH, O'Halloran R, Sorkness RL, Grist TM. Functional lung imaging using hyperpolarized gas MRI. J Magn Reson Imaging 2007 May;25(5):910-23.

• Driehuys B, Cofer GP, Pollaro J, Mackel JB, Hedlund LW, Johnson GA. Imaging alveolar-capillary gas transfer using hyperpolarized ¹²⁹Xe MRI. Proc Natl Acad Sci U S A 2006 Nov 28;103(48):18278-83.